General Information

  • ID:  hor003676
  • Uniprot ID:  P85043
  • Protein name:  Periviscerokinin
  • Gene name:  NA
  • Organism:  Ixodes ricinus (Common tick) (Acarus ricinus)
  • Family:  Periviscerokinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Ixodes (genus), Ixodinae (subfamily), Ixodidae (family), Ixodoidea (superfamily), Ixodida (order), Parasitiformes (superorder), Acari (subclass), Arachnida (class), Chelicerata (subphylum), Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0003674 molecular_function
  • GO BP:  GO:0006940 regulation of smooth muscle contraction; GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  PALIPFPRV
  • Length:  9
  • Propeptide:  PALIPFPRV
  • Signal peptide:  NA
  • Modification:  T9 Valine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myotropic activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003676_AF2.pdbhor003676_ESM.pdb

Physical Information

Mass: 115213 Formula: C50H80N12O10
Absent amino acids: CDEGHKMNQSTWY Common amino acids: P
pI: 10.55 Basic residues: 1
Polar residues: 0 Hydrophobic residues: 5
Hydrophobicity: 86.67 Boman Index: 375
Half-Life: >20 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: ? Aliphatic Index 130
Instability Index: 6151.11 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  16289040
  • Title:  Identification of Tick Periviscerokinin, the First Neurohormone of Ixodidae: Single Cell Analysis by Means of MALDI-TOF/TOF Mass Spectrometry